Yayoi Onda

Daisuke Yokoyama Address
Department of Food and Applied Life Sciences, Yamagata University
TEL +81-235-28-2948
E-mail yonda[-at-]tds1.tr.yamagata-u.ac.jp
Post April 1, 2011-
Research Field Biochemistry, Cell Biology
Key Words
Redox Regulation, Disulfide Bond Formation, Plant
Research Interests

Research in my lab focuses on redox regulation of organellar and cellular function in plants. Disulfide bond formation in the endoplasmic reticulum (ER) involves electron transfer and generates hydrogen peroxide as a by-product. Plant cells, especially endosperm cells, synthesize large amounts of disulfide-rich proteins that are physicochemically and structurally diverse. We study the molecular mechanisms regulating multiple pathways for disulfide bond formation in the ER of plant cells using molecular and biochemical approaches.

Selected references:
Onda Y, et al. Distinct roles of protein disulfide isomerase and P5 sulfhydryl oxidoreductases in multiple pathways for oxidation of structurally diverse storage proteins in rice. Plant Cell 23: 210-223 (2011).
Onda Y, et al. ER membrane-localized oxidoreductase Ero1 is required for disulfide bond formation in the rice endosperm. Proc Natl Acad Sci USA 106: 14156-14161 (2009).


To make optimal use of available resources, plant cells have evolved redox mechanisms regulating fundamental processes in the organelles, such as inorganic compound assimilation, starch synthesis, and oxidative protein folding. Research in my lab focuses on understanding the molecular mechanisms by which plant cells maintain redox environment and metabolic flow.